Peptide Recognition That Determine the Degree of Degeneracy in Structural Features of Autoreactive TCR
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Molecular basis for recognition of an arthritic peptide and a foreign epitope on distinct MHC molecules by a single TCR.
KRN TCR transgenic T cells recognize two self-MHC molecules: a foreign peptide, bovine RNase 42-56, on I-Ak and an autoantigen, glucose-6-phosphate isomerase 282-294, on I-Ag7. Because the latter recognition event initiates a disease closely resembling human rheumatoid arthritis, we investigated the structural basis of this pathogenic TCR's dual specificity. While peptide recognition is altered...
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تاریخ انتشار 1998